◀ Back to CXCL10
CXCL10 — CXCL12
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CXCL10
→
CXCL12
(increases)
Oh et al., J Immunol 2001*
Evidence: SDF-1alpha treatment induced expression of the chemokines monocyte chemoattractant protein-1, IL-8, and IFN-gamma-inducible protein-10.
-
Reactome Reaction:
CXCL10
→
CXCL12
(reaction)
Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
Text-mined interactions from Literome
Jinquan et al., J Immunol 2001
:
gamma IP-10 or Mig has
induced neither chemotaxis nor adhesion in GM-CSF stimulated Cbl-b blocked CD34 ( + ) hemopoietic progenitors, whereas
SDF-1alpha induces both chemotaxis and adhesion in these cells
Schuh et al., J Immunol 2002
(Asthma...) :
Interestingly, at day 3 after conidia, neutrophil recruitment and airway hyperresponsiveness in CXCR2-/- mice was
mediated by inflammatory
protein-10/CXCL10 and, to a lesser degree,
MIG/CXCL9
Sharma et al., Molecular cancer 2003
(Carcinoma, Lewis Lung) :
In vivo depletion of
IP-10/CXCL10 ,
MIG/CXCL9 or IFNgamma significantly
reduced the anti-tumor efficacy of SLC/CCL21
Shen et al., Zhonghua Yi Xue Za Zhi 2003
(Enterovirus Infections) :
The expression of MIP-2 and
IP-10 was
induced post-infection, while
SDF-1 , MCP-1, MCP-2, MCP-3, MCP-5, MDC, FKN and Ltn were constitutively expressed in myocardial tissue
Yu et al., J Reprod Immunol 2007
:
After orchiectomy or ovariectomy, the expression of ICAM-1,
CXCL12 and P-selectin mRNA in the examined organs
increased , except JAM-1 in male and
CXCL12 in female
Ierano et al., Cell cycle (Georgetown, Tex.) 2009
(Neoplasms) :
CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand,
CXCL12 and P-Erk was specifically
induced by
CXCL12
McKimmie et al., Biochem Biophys Res Commun 2010
:
Bacterial associated molecules
induced the preferential expression of CCL2,
CXCL1 , CCL20 and CCL3 whilst a virus associated dsRNA analogue preferentially up-regulated
CXCL10 and CCL5
Geluk et al., J Immunol 2011
(Leprosy) :
Most CD8 ( + ) T cells produced IFN-?, but distinct IFN-? ( + ) /TNF-a ( + ) populations were detected simultaneously with significant secretion of
CXCL10/IFN-? induced protein 10,
CXCL9/MIG , and VEGF