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CXCL16 — TNF
Text-mined interactions from Literome
Cheng et al., J Immunol 2002
:
We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses
TNF-alpha induced production of the neutrophil-specific chemokine
IL-8/CXCL8
Hardaker et al., FASEB J 2004
(Inflammation...) :
In primary cultured hASM cells taken from normal donors,
CXCL10 protein expression was
induced by IFN-gamma and
TNF-alpha , cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Juarranz et al., Rheumatology (Oxford) 2004
(Arthritis, Rheumatoid...) :
The effects of VIP on basal or
tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ),
CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
van der Voort et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid) :
In vitro studies revealed that monocytes started to express CXCL16 upon differentiation into macrophages, and that RA SF and
tumor necrosis factor (TNF) enhanced
CXCL16 expression
Hara et al., Int Immunol 2006
:
TNFalpha induced expression of
CXCL16 depends on NFkappaB, p38 MAPK and PKA
Green et al., J Infect Dis 2006
:
Analysis of > 1500 ARE containing cellular mRNAs, by use of microarrays, revealed that
CXCL-8 and other newly identified ARE genes were
induced by
TNF- alpha in Huh7 cells and were coordinately regulated
De Plaen et al., Immunology 2006
:
In conclusion,
CXCL2 gene is expressed in enterocytes in
response to both
TNF and LPS
Kamohara et al., Int J Oncol 2007
(Inflammation...) :
Induction of interleukin-8 (
CXCL-8 ) by
tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
Son et al., Cancer Biol Ther 2007
(Carcinoma...) :
ID8 cells constitutively expressed
CXCL16 and CCL2, but only CCL2 expression was
enhanced by LPS, IL-1 and
TNF
Funakoshi-Tago et al., Biochem Pharmacol 2008
:
As a result,
TNFalpha induced expression of inflammatory cytokines,
CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib
Lee et al., J Immunol 2008
:
IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but
synergized with
TNF-alpha for induction of
CXCL8 , CXCL1, and CCL20 mRNAs
Funakoshi-Tago et al., Cytokine 2009
:
Interestingly, we observed that
TNFalpha induced expression of IL-6,
CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Subileau et al., J Neuropathol Exp Neurol 2009
(Inflammation...) :
Tumor necrosis factor strongly
increased the production of CCL2, CCL5, and
CXCL8 ; interferon gamma upregulated CXCL10 exclusively
Heuvelin et al., PloS one 2009
(Colitis) :
TNFalpha induced chemokine (
CXCL8 ) secretion and alteration of NF-kappaB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting
John et al., J Immunol 2009
(Asthma) :
Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the
CXCL8 promoter of asthmatic HASM cells both in the
presence and absence of
TNF-alpha stimulation
Földes et al., PloS one 2010
:
Expression of downstream TLR signalling pathways was demonstrated in hESC, and IL-1beta,
TNFalpha and INFgamma, which bypass the TLRs,
stimulated CXCL8 release
Stich et al., Res Vet Sci 2011
:
Lipopolysaccharide was a more potent inducer of IL-1ß and
CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria
induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Robins et al., Am J Respir Cell Mol Biol 2011
(Asthma...) :
In contrast to epithelial and endothelial cells,
TNF-a stimulated
CXCL8 synthesis was dependent on ERK1/ERK2 but not on p38 MAPK
Kanda et al., Endocrinology 2011
(Psoriasis) :
Visfatin enhanced
TNF-a induced
CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Chang et al., J Allergy Clin Immunol 2012
(Asthma) :
In patients with severe asthma, dexamethasone caused less suppression of CCL11 and
CXCL8 release
induced by
TNF-a
Xu et al., Pharmacol Res 2013
:
TNF-a induced
CXCL8 production by A549 cells : Involvement of the non-neuronal cholinergic system ... In A549 cells,
TNF-a increased the release of
CXCL8 and ACh and the expression of the subtype 3 MR ( M3R ) ... Furthermore,
TNF-a induced
CXCL8 secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine ... Taken as a whole, these results suggest that ACh release by A549 cells enhances
TNF-a induced
CXCL8 secretion through activation of the M3R ... Our results suggest that the
TNF-a induced secretion of
CXCL8 in A549 cells is regulated by the release of ACh, the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways
Xu et al., J Immunol 2013
(Psoriasis) :
Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and
TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and
CXCL8/IL-8 in human primary keratinocytes
Kobayashi et al., Br J Pharmacol 2013
:
Corticosteroid sensitivity was determined by IC50 /EC50 of dexamethasone ( Dex ) on
TNF-a induced
CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells ( PBMC ) from COPD patients
Son et al., Journal of inflammation (London, England) 2013
:
Finally, CCL20 and
CXCL8 responded synergistically in
response to EGF and
TNF in OVCAR-3 and SKOV-3 cells