Gene interactions and pathways from curated databases and text-mining

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CXCL2 — CXCR1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gouwy et al., J Leukoc Biol 2009 : In turn, the induced CXCL8 synergized with CCL2 for mononuclear cell chemotaxis, and the chemotactic effect was mediated by CXCR1/CXCR2 , because CXCL8 receptor antagonists or antibodies were capable of blocking the synergy, while keeping the responsiveness to CCL2 intact
Nasser et al., J Immunol 2009 : CXCL8 ( also known as IL-8 ) activates CXCR1 and CXCR2 to mediate neutrophil recruitment and trigger cytotoxic effect at sites of infection
Singh et al., Microvasc Res 2011 : Additionally, we examined the mechanism of CXCL8 dependent CXCR1 and/or CXCR2 mediated phenotypic changes by evaluating ERK phosphorylation and cytoskeletal rearrangement and observed inhibition of ERK phosphorylation and cytoskeletal rearrangement in HMEC-1-shCXCR1, HMEC-1-shCXCR2 and HMEC-1-shCXCR1/2 cells
Sundaram et al., Lab Invest 2013 (Osteitis Deformans) : Moreover, CXCL5 increased ( 5.2-fold ) CXCR1 receptor expression in these cells