Gene interactions and pathways from curated databases and text-mining

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CXCR4 — FOXO1

Text-mined interactions from Literome

Tomescu et al., Lab Invest 2004 (Rhabdomyosarcoma, Embryonal) : First, we demonstrated in both short-term and long-term systems that PAX3-FKHR upregulates expression of the gene encoding the chemokine receptor CXCR4
Tarnowski et al., Mol Cancer Res 2010 (Rhabdomyosarcoma) : The upregulation of CXCR4 and downregulation of CXCR7 expression by PAX3-FKHR or hypoxia may give SDF-1 an advantage to better engage the CXCR4 receptor, thus increasing RMS motility