Gene interactions and pathways from curated databases and text-mining

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CYP7A1 — FOXO1

Text-mined interactions from Literome

Li et al., J Biol Chem 2006 : Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes : roles of forkhead box O1 and sterol regulatory element binding protein 1c
Li et al., J Lipid Res 2008 : Smad3, FoxO1 , and HNF4alpha synergistically stimulated rat Cyp7a1 gene transcription ... Smad3, FoxO1 , and HNF4alpha synergistically stimulated rat Cyp7a1 gene transcription
Li et al., Biochim Biophys Acta 2009 (Insulin Resistance) : This study investigated the roles of FoxO1 in the regulation of cholesterol 7alpha-hydroxylase ( CYP7A1 ) gene expression in primary human hepatocytes ... Adenovirus mediated expression of a phosphorylation defective and constitutively active form of FoxO1 ( FoxO1-ADA ) inhibited CYP7A1 mRNA expression and bile acid synthesis, while siRNA knockdown of FoxO1 resulted in a approximately 6-fold induction of CYP7A1 mRNA in human hepatocytes ... Insulin caused rapid exclusion of FoxO1 from the nucleus and resulted in the induction of CYP7A1 mRNA expression, which was blocked by FoxO1-ADA ... Impaired regulation of FoxO1 may cause down-regulation of CYP7A1 gene expression and contribute to dyslipidemia in insulin resistance
Park et al., Exp Mol Med 2011 : However, ectopic expression of FOXO1 increased the rat CYP7A1-, but mildly reduced human CYP7A1-promoter activities in a dose dependent manner