Okada et al., J Endocrinol 2001
:
To evaluate mechanisms of cell proliferation in the fetal female rat reproductive tract, diethylstilbestrol (DES) effects on cell division and estrogen receptor ( ER ), epidermal growth factor (EGF) and EGF receptor (EGF-R) expressions were determined from gestational day ( GD ) 15.5 to 21.5 ... Müllerian duct EGF immunoreactivity was suppressed by DES compared with oil
Johnstone et al., Carcinogenesis 1984
:
DES , at all concentrations other than 10 ( -6 ) M, in the presence of EGF inhibits cell proliferation but does not prevent the EGF induced cellular hypertrophy, reduction in stratification or reduction in the fraction of differentiating cells