Gene interactions and pathways from curated databases and text-mining

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DUSP4 — FOXO1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: DUSP4 → FOXO1 (increases, DUSP4 Activity) Modur et al., J Biol Chem 2002*
    Evidence: Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of PTEN mutations in prostate cancer, we used microarrays to identify genes regulated by FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 p...