Gene interactions and pathways from curated databases and text-mining

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E2F1 — IRF3

Text-mined interactions from Literome

Xu et al., Mol Biol Rep 2010 : Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1
Xu et al., Immunogenetics 2011 : Here we report that the transcription factor E2F1 negatively regulates the basal transcriptional activity of IRF-3 and deregulates IRF-3 expression at mRNA level ... Overexpression of E2F1, but not a mutant E2F1 , represses the IRF-3 promoter activity in reporter gene assays while knocking down of endogenous E2F1 by shRNA strategy results in enhanced IRF-3 promoter activity ... These results suggest that E2F1 negatively regulates IRF-3 transcription through binding to the E2F consensus binding site