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Text-mined interactions from Literome
Haug et al., J Mol Cell Cardiol 2001
:
In the present study, we have investigated the
effect of native
LDL ( nLDL ) and oxidatively modified LDL ( oxLDL ) on ET-1 synthesis and
endothelin receptor expression in cultured human coronary artery smooth muscle cells and human monocyte derived macrophages ... In coronary smooth muscle cells,
endothelin A receptor expression was slightly
increased by
LDL , whereas endothelin A receptor was not detectable in monocyte derived macrophages
Bousette et al., Can J Physiol Pharmacol 2003
(Arteriosclerosis...) :
We also discuss
regulation of
endothelin by angiotensin II, reactive oxygen species, thrombin, aging, and
LDL in the cardiovascular system
Boulanger et al., Circ Res 1992
:
The
Ox-LDL stimulated release of
endothelin was mimicked by acetylated low density lipoprotein and abolished by downregulation of protein kinase C by phorbol ester
Muller et al., Experimental biology and medicine (Maywood, N.J.) 2006
:
Although it has been previously shown that hypercholesterolemia stimulates the endothelin system, the
effects of increased levels of
LDL on endothelial
endothelin receptors have not been previously studied
He et al., Atherosclerosis 1996
:
The aim of this study was to determine how oxidized
LDL affects
endothelin secretion by endothelial cells, monocytes and macrophages ... Extensively oxidized
LDL inhibited
endothelin secretion from cultured endothelial cells ... Acetyl
LDL slightly
increased basal
endothelin release by endothelial cells, but native LDL or mildly oxidized LDL had no significant effect ... Overall, the present findings argue against a stimulatory
effect of oxidized
LDL on
endothelin release as contributing to increased vasoreactivity in atherosclerosis