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EDN3 — EPHB2
Text-mined interactions from Literome
Vichi et al., J Biol Chem 1999
:
For example, nine point mutations within TM7 of the ETB were identified that prevented
endothelin stimulated
ERK activation
Leopoldt et al., J Cell Physiol 2000
:
Stimulation of these cells with bombesin, lysophosphatidic acid (LPA),
endothelin , and platelet derived growth factor ( PDGF )
led to a marked increase in the tyrosine phosphorylation of these focal adhesion proteins and in
ERK activation
Cramer et al., Eur J Biochem 2001
(MAP Kinase Signaling System) :
Using mutated ET receptors with selective G-protein coupling we found that endothelin induced stimulation of G ( alpha ) q, but not of G ( alpha ) i or G ( alpha ) s, is essential for
endothelin mediated
ERK activation
Morishita et al., Neurosci Res 2007
:
Endothelin induced ERK phosphorylation was independent of integrin ligands, and an inhibitor of G ( q/11 ), YM-254890, as well as pertussis toxin, partially inhibited
endothelin stimulated phosphorylation of Raf-1 and
ERK ... A PKC inhibitor and down-regulation of PKC prevented
endothelin induced phosphorylation of paxillin and
ERK
Dorado et al., Nephrol Dial Transplant 2008
:
In cultured human mesangial cells,
Erk5 was
activated by foetal calf serum ( FCS ), high glucose,
endothelin-1 , platelet activating factor (PAF), epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 )
Chen et al., BMC cell biology 2009
:
Role of
ERK/MAPK in
endothelin receptor signaling in human aortic smooth muscle cells
Aquilla et al., J Biol Chem 1996
:
The observed ERK activation appeared to be mediated by heterotrimeric G proteins, since ectopic expression of a transducin alpha-subunit inhibited
endothelin stimulated
ERK activation
Zou et al., J Biol Chem 1996
:
Overexpression of a dominant negative mutant of Raf-1 completely suppressed
ERK2 activation by AngII,
endothelin-1 , and insulin
Alexandrov et al., Mol Pharmacol 1998
:
In Rat-1 fibroblasts,
endothelin-1 and a protein kinase C-stimulating phorbol ester stimulated extracellular signal regulated kinase ( ERK ), whereas phenylephrine, acting at stably transfected human alpha1A-adrenoceptors,
inhibited basal and endothelin-1- and phorbol ester stimulated
ERK