Gene interactions and pathways from curated databases and text-mining

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EGR1 — MAPK14

Text-mined interactions from Literome

Bernal-Mizrachi et al., J Biol Chem 2000 : Pharmacological inhibition of the Egr-1 induction by H89 ( 48 % ) and calmidazolium ( 35 % ), but not by mitogen activated protein kinase/extracellular signal regulated kinase kinase 1 and 2 or phosphatidylinositol 3-kinase inhibitors, implied that protein kinase A and Ca ( 2+ ) /calmodulin pathways are involved
Bea et al., Circ Res 2003 (MAP Kinase Signaling System) : Furthermore, C pneumoniae stimulated phosphorylation of ERK1/2 and Elk-1 and pharmacological inhibition of mitogen activated protein kinase activity reduced the expression of TF and Egr-1
Jones et al., J Cell Physiol 2003 (Hyperoxia) : MEK inhibitor PD98059, but not inhibitors of p38 MAPK or PI3-kinase pathway, prevented Egr-1 induction by hyperoxia
Fujita et al., J Clin Invest 2004 (Ischemia...) : In vitro, hypoxia/reoxygenation mediated induction of Egr-1 in MPs was suppressed by inhibition of PKCbeta, ERK1/2, and JNK, but not by inhibition of p38 MAPK
Chen et al., J Cell Biochem 2004 : Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen activated protein kinase dependent phosphorylation of ELK-1
Buchwalter et al., Mol Cell Biol 2005 : They form ternary complexes with serum response factor (SRF) on serum response elements of immediate early genes such as c-fos and egr-1 and mediate responses to growth factors and mitogen activated protein kinase signaling
Mishra et al., Proc Natl Acad Sci U S A 2006 (Anoxia...) : In this study we tested the hypothesis that inhibition of mitogen activated protein kinase dependent Egr-1 expression may be pivotal in CO-mediated ischemic protection
Ke et al., J Biol Chem 2006 (Lymphoma, B-Cell...) : Promoter truncation experiments suggested that several serum response elements are required for MAPK mediated egr-1 expression ... Unlike ERK and JNK, p38 MAPK reduces constitutive expression of egr-1
Yasuoka et al., Am J Pathol 2009 (Pulmonary Fibrosis) : Egr-1 was up-regulated by IGFBP-5 in a MAPK dependent manner and bound to nuclear IGFBP-5
Allen et al., Toxicol Appl Pharmacol 2010 (MAP Kinase Signaling System) : Results from these studies demonstrate that activation of MAPK signaling is required for upregulation of Egr-1 by bile acids in hepatocytes and for upregulation of Egr-1 in the liver during cholestasis
Horita et al., J Comp Neurol 2010 : Dusp1 is an inactivator of mitogen activated protein kinase ( MAPK ), and MAPK activates expression of egr1 , one of the most commonly studied IEGs, as determined in cultured cells
Shen et al., Am J Pathol 2011 (Pulmonary Disease, Chronic Obstructive) : The accumulation of EGR-1 and GGPPS was induced by MAPK/ERK pathway activation when Beas-2B human bronchial epithelial cells were exposed to cigarette smoke extract (CSE)
Shen et al., J Biol Chem 2011 (Diabetes Mellitus, Type 2...) : In this report, we found that chronic exposure to hyperinsulinism caused persistent Erk/MAPK activity in adipocytes and enhanced insulin resistance in an Egr-1 dependent manner
Haschemi et al., PloS one 2011 (Inflammation) : In addition to PPAR? SUMOylation, CO-activated p38 MAPK was responsible for Egr-1 repression
Iyoda et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Our data demonstrate that activation of ERK1/2 and JNK, but not p38 MAPK , is required for LPA induced Egr-1 expression in smooth muscle cells
Beno et al., J Biol Chem 1995 : Protein kinase C and mitogen activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction ... These results suggest that 1 ) D3 stimulates MAPK via a protein kinase C-dependent pathway, 2 ) D3-induced Egr expression can occur via a pathway independent of Ras induced Raf, and 3 ) D3 absolutely requires MAPK activity for Egr expression