Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
ESR1
→
Complex of EP300-NCOA3
(directlyIncreases, EP300/NCOA3 Activity)
Evidence: The C-terminal region of the p160 proteins mediates interaction with other factors with a role in ER signaling including CBP (CREB-binding protein), p300 and arginine methyltransferase 1 (CARM-1) [32].
OpenBEL Selventa BEL large corpus:
ESR1
→
Complex of EP300-NCOA3
(directlyIncreases, EP300/NCOA3 Activity)
Evidence: ER coregulators are also targets of many of the same signaling pathways that affect ER directly. MAPK can phosphorylate p160 coactivators NCoA-1 and NCoA-3, and can enhance their transcriptional activities partly by facilitating their interaction with CBP/p300 [87,88].