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EPHB2 — LRP1
Text-mined interactions from Literome
Webb et al., J Cell Sci 2000
(Fibrosarcoma...) :
By regulating the uPA/uPAR system,
LRP may also
regulate ERK activation, cellular migration, and invasion
Ma et al., J Cell Biol 2002
:
In addition to Rac1,
LRP-1 suppressed activation of extracellular signal regulated kinase (
ERK ) in MEFs ; however, it was Rac1 ( and not ERK ) that was responsible for the effects of LRP-1 on MEF migration ... Thus,
LRP-1 regulates two signaling proteins in the same cell ( Rac1 and
ERK ), both of which may impact on cell migration ... Thus,
LRP-1 regulates two signaling proteins in the same cell ( Rac1 and
ERK ), both of which may impact on cell migration
Langlois et al., PloS one 2010
:
Moreover, we found that
LRP-1 is tethered to the actin network and to focal adhesion sites and
controls ERK and JNK targeting to talin-rich structures
Geetha et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
The simultaneous stimulation of a receptor tyrosine kinase by its cognate ligand and of
LRP-1 ( by lactoferrin or LDL )
resulted in sustained activation of
ERK , which was redirected to the cytoplasm