Gene interactions and pathways from curated databases and text-mining

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EPHB2 — LRP1

Text-mined interactions from Literome

Webb et al., J Cell Sci 2000 (Fibrosarcoma...) : By regulating the uPA/uPAR system, LRP may also regulate ERK activation, cellular migration, and invasion
Ma et al., J Cell Biol 2002 : In addition to Rac1, LRP-1 suppressed activation of extracellular signal regulated kinase ( ERK ) in MEFs ; however, it was Rac1 ( and not ERK ) that was responsible for the effects of LRP-1 on MEF migration ... Thus, LRP-1 regulates two signaling proteins in the same cell ( Rac1 and ERK ), both of which may impact on cell migration ... Thus, LRP-1 regulates two signaling proteins in the same cell ( Rac1 and ERK ), both of which may impact on cell migration
Langlois et al., PloS one 2010 : Moreover, we found that LRP-1 is tethered to the actin network and to focal adhesion sites and controls ERK and JNK targeting to talin-rich structures
Geetha et al., J Biol Chem 2011 (MAP Kinase Signaling System) : The simultaneous stimulation of a receptor tyrosine kinase by its cognate ligand and of LRP-1 ( by lactoferrin or LDL ) resulted in sustained activation of ERK , which was redirected to the cytoplasm