Tsokas et al., J Neurosci 2007
(MAP Kinase Signaling System) :
The role of ERK in regulating PDK1 and Akt, with their extensive effects on cellular function, has important implications for the coordinated response of the neuron to LTP inducing stimulation
Yang et al., Eur J Pharmacol 2010
:
These results suggest that plumbagin activates NAD ( P ) H oxidase, Src, and PI3K, and that the activated PI3K or PDK1 subsequently stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells