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BRCA1 — EZH2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gonzalez et al., Oncogene 2009
(Breast Neoplasms...) :
Downregulation of
EZH2 decreases growth of estrogen receptor negative invasive breast carcinoma and
requires BRCA1 ... Taken together, we show that
EZH2 is important in ER-negative breast cancer growth in vivo and in vitro, and that
BRCA1 is
required for the proliferative effects of EZH2
Gonzalez et al., Cancer Res 2011
(Breast Neoplasms...) :
EZH2 induced
BRCA1 nuclear export, aneuploidy, and mitotic defects were prevented by treatment with the PI3K inhibitors LY294002 or wortmannin
Wang et al., EMBO J 2013
:
The BRCA1 binding region in EZH2 overlaps with the noncoding RNA ( ncRNA ) -binding domain, and
BRCA1 expression
inhibits the binding of
EZH2 to the HOTAIR ncRNA