Gene interactions and pathways from curated databases and text-mining

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BCL10 — FASLG

Text-mined interactions from Literome

Biswas et al., Mol Cell Biochem 2001 (Breast Neoplasms...) : Overexpression of Bcl-XL leads to inhibition of paclitaxel induced FasL expression and apoptosis
Chandrasekar et al., J Biol Chem 2004 (Inflammation) : Treatment of HCMEC with IL-18 increases 1 ) NF-kappaB DNA binding activity ; 2 ) induces kappaB-driven luciferase activity ; 3 ) induces IL-1beta and TNF-alpha expression via NF-kappaB activation ; 4 ) inhibits antiapoptotic Bcl-2 and Bcl-X ( L ) ; 5 ) up-regulates proapoptotic Fas, Fas-L, and Bcl-X ( S ) expression ; 6 ) induces fas and Fas-L promoter activities via NF-kappaB activation ; 7 ) activates caspases-8, -3, -9, and BID ; 8 ) induces cytochrome c release into the cytoplasm ; 9 ) inhibits FLIP ; and 10 ) induces HCME cell death by apoptosis as seen by increased annexin V staining and increased levels of mono- and oligonucleosomal fragmented DNA
Gravina et al., Prostate 2010 (Neoplasms, Experimental...) : This combined treatment up-regulated the expression of FasL , phospho-FADD, p16 ( INKA ), Bax, Bak, and p21 ( WAF1 ), and inhibited FLIP, Bcl-2, and Bcl-XL expression
Fulda et al., Cancer Res 1998 (Neuroblastoma) : After Doxo treatment, enhanced CD95/CD95-L expression and caspase-8 activation were not blocked by Bcl-2 or Bcl-X ( L ) and were found in cells with a mitochondrial transmembrane potential ( delta psi ( m ) ) that was still normal ( delta psi ( m ) high cells )