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FGF2 — SMAD3

Text-mined interactions from Literome

Yang et al., Oncogene 2008 (Carcinoma...) : In summary, these data show that TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and that this effect is mediated in part through a TbetaRII/Smad3 dependent upregulation of FGF-2 expression and release
Cushing et al., FASEB J 2008 (Fibrosis...) : Using an exogenous Smad-responsive transcriptional promoter reporter, we show that Smad activity is repressed by FGF-2 , likely an effect of the fact that FGF-2 treatment prevents the nuclear localization of Smads in these cells
Stuhlmiller et al., Development 2012 : Our results identify an early requirement for FGF/MAPK signaling in amniote neural crest induction and suggest an intriguing role for FGF mediated Smad inhibition in ectodermal development