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FGF20 — FGFR4

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9 → FGFR1/FGFR2/FGFR3/FGFR4 (protein-protein, activation)
• Reactome Reaction: FGF20 → FGFR4 (indirect_complex) Mohammadi et al., Cytokine Growth Factor Rev 2005, Zhang et al., J Biol Chem 2006
• Reactome Reaction: FGF20 → FGFR4 (direct_complex) Hart et al., Mol Biol Cell 2001, Mohammadi et al., Nature 1992, Mohammadi et al., Mol Cell Biol 1991, Mohammadi et al., Mol Cell Biol 1996
• Reactome Reaction: FGF20 → FGFR4 (reaction) Carpenter et al., Exp Cell Res 1999, Hart et al., Mol Biol Cell 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Mohammadi et al., Nature 1992, Agazie et al., Oncogene 2003, Mohammadi et al., Cytokine Growth Factor Rev 2005, Mohammadi et al., Mol Cell Biol 1991, Zhang et al., J Biol Chem 2006, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Mohammadi et al., Mol Cell Biol 1996, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
• WikiPathways ESC Pluripotency Pathways: FGF1/FGF16/FGF6/FGF19/FGF22/FGF10/FGF9/FGF20/FGF11/FGF17/FGF18/FGF14/FGF23/FGF5/FGF2/FGF12/FGF21/FGF3/FGF7/FGF8/FGF4 → FGFR1/FGFR3/FGFR4/FGFR2 (activation)
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  

Text-mined interactions from Literome

Wang et al., Growth Factors 2000 : The biological activities of fibroblast growth factors ( FGF ) are mediated by specific cell membrane receptors ( FGFR ), which have three immunoglobulin-like IgG domains in the extracellular region
Pellegrini et al., Curr Opin Struct Biol 2001 : Fibroblast growth factors ( FGFs ) are among the best studied heparin binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR
Zhang et al., Development 2003 : These experiments show that FGFR4a mediated FGF signaling is necessary for the correct specification of retinal cell types
Anderson et al., J Neurochem 2005 : Dendrimeric FRM peptide was 125-fold more active and stimulated FGFR activation, FGFR dependent and FGF-mimetic neurite outgrowth and cell survival ( but not proliferation )
Buratini et al., Biol Reprod 2007 : Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B
Wu et al., Proc Natl Acad Sci U S A 2009 (Obesity) : Further, FGF19 activated FGFR4 signaling in the presence or absence of betaKlotho, but activation of FGFRs 1c, 2c, or 3c was completely betaKlotho dependent
Mencarelli et al., J Cell Mol Med 2010 (Atherosclerosis) : In the intestine FXR induces the release of fibroblast growth factor 15 ( FGF15 ) ( or FGF19 in human ), which activates hepatic FGF receptor 4 (FGFR4) signalling to inhibit bile acid synthesis
Li et al., Mol Cell Endocrinol 2012 : In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho, FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects ... In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho, FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Ahmad et al., Biochim Biophys Acta 2012 (Cell Transformation, Neoplastic...) : FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy
Itoh et al., Development 1996 : These results suggest that the FGFR mediated FGF signaling ( 1 ) blocks terminal differentiation of myogenic cells within the somite and ( 2 ) sustains myoblast migration to limb buds from the somite, and that ( 3 ) down-regulation of FGFRs or FGFR signaling is involved in mechanisms triggering terminal differentiation of the limb muscle mass during avian embryogenesis
McKeehan et al., Prog Nucleic Acid Res Mol Biol 1998 : Divalent cations cooperate with the FGFRHS to conformationally restrict FGFRTK trans-phosphorylation, which causes depression of kinase activity and facilitates appropriate activation of the FGFR complex by FGF