Gene interactions and pathways from curated databases and text-mining

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FOS — TLR7

Text-mined interactions from Literome

Wang et al., Nat Immunol 2006 : Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1 , transcriptional activators of innate immunity
Hu et al., J Leukoc Biol 2007 : IFN-gamma suppression of TLR induced activation of AP-1 and downstream target genes challenges current concepts about the inflammatory role of AP-1 proteins in macrophage activation and is consistent with a role for AP-1 in the generation of noninflammatory osteoclasts
Wen et al., J Exp Med 2010 (Peritonitis...) : Rac1 activation is accompanied by JNK ( c-Jun N-terminal kinase ) and NF-?B activation, culminating in TLR induced binding of NF-?B and AP-1 to the promoters of inflammatory cytokines