Gene interactions and pathways from curated databases and text-mining

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FOXO1 — FOXO3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kino et al., Diabetes 2005 (Acquired Immunodeficiency Syndrome...) : This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative effect of insulin on Foxo3a induced transactivation of a FOXO-responsive promoter
Lynch et al., Mol Cancer Res 2005 (Disease Progression...) : Together, reduced FOXO3a expression coupled to FOXO3a hyperphosphorylation would suppress FOXO transcriptional activity
Essaghir et al., J Biol Chem 2009 : The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors ... Conversely, ectopic FOXO3 activation blocked the proliferation of fibroblasts and induced the expression of FOXO1, FOXO4 , and p27-KIP1 ... Conversely, ectopic FOXO3 activation blocked the proliferation of fibroblasts and induced the expression of FOXO1 , FOXO4, and p27-KIP1 ... Using luciferase reporter assays and chromatin immunoprecipitations, we identified a conserved FOXO binding site in the promoter of the FOXO1 gene, which was required for regulation by PDGF, and mediated the up-regulation of FOXO1 by itself and by FOXO3 ... Altogether, our results suggest that the expression of FOXO1 and FOXO4 genes is stimulated by FOXO3 and possibly by other FOXO factors in a positive feedback loop, which is disrupted by growth factors
Zhou et al., Autophagy 2012 : In this study, we showed that FOXO3 induced a transcription dependent autophagy, and FOXO1 was required for this process ... Our data also showed that FOXO3 overexpression did not increase the expression of FOXO1 at the protein level, although FOXO3 was capable of binding the promoter region of FOXO1 and inducing an increase in the transcription of FOXO1 mRNA ... Furthermore, our results showed that FOXO3 promoted the translocation of FOXO1 from the nucleus to the cytoplasm, resulting in an increase in FOXO1 induced autophagy