Gene interactions and pathways from curated databases and text-mining

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FOXP3 — IL12A

Text-mined interactions from Literome

Brahmachari et al., J Immunol 2009 : IL-12p40 ( 2 ) dose-dependently inhibited the expression of Foxp3 and CD25, but not CD4
Turnquist et al., Blood 2010 (Inflammation) : Thus, GSK-3 activity in DC is regulated via signaling linked to mTOR and modulates their capacity both to produce IL-12p40/p70 and induce forkhead box p3 in CD4 ( + ) T cells under inflammatory conditions
Ganesh et al., PloS one 2011 : Here, we examined the differential effects of IL-12 and IL-1ß on Foxp3 expression in T cells when activated in the presence and absence of DCs ... Exogenous IL-12 abolished, but IL-1ß enhanced , the ability of GM-CSF exposed tolerogenic DCs to promote Foxp3 expression
Prochazkova et al., Immunobiology 2012 : On the molecular level, IL-12 inhibited the expression of the lineage specific transcription factors Foxp3 and ROR?t in developing Tregs and Th17 cells, respectively