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FOXP3 — IL12A
Text-mined interactions from Literome
Brahmachari et al., J Immunol 2009
:
IL-12p40 ( 2 ) dose-dependently
inhibited the expression of
Foxp3 and CD25, but not CD4
Turnquist et al., Blood 2010
(Inflammation) :
Thus, GSK-3 activity in DC is regulated via signaling linked to mTOR and modulates their capacity both to produce
IL-12p40/p70 and
induce forkhead box p3 in CD4 ( + ) T cells under inflammatory conditions
Ganesh et al., PloS one 2011
:
Here, we examined the differential
effects of
IL-12 and IL-1ß on
Foxp3 expression in T cells when activated in the presence and absence of DCs ... Exogenous
IL-12 abolished, but IL-1ß
enhanced , the ability of GM-CSF exposed tolerogenic DCs to promote
Foxp3 expression
Prochazkova et al., Immunobiology 2012
:
On the molecular level,
IL-12 inhibited the expression of the lineage specific transcription factors
Foxp3 and ROR?t in developing Tregs and Th17 cells, respectively