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FOXP3 — TLR8
Text-mined interactions from Literome
Bell et al., J Immunol 2007
:
We hypothesized that the transcription factor
forkhead box P3 (FOXP3) regulates the expression of
TLR family members in human Treg cells
Kiniwa et al., Clin Cancer Res 2007
(Prostatic Neoplasms) :
Our study shows that like CD4 ( + ) CD25 ( + ) Treg cells, CD8 ( + )
Foxp3 ( + ) Treg cells present in prostate tumor derived TILs suppress immune responses and that their suppressive function can be
regulated by
TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + )
/CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed