Rai et al., PloS one 2010
(Disease Models, Animal...) :
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich 's ataxia patients and in a mouse model
Soragni et al., J Child Neurol 2012
(Disease Models, Animal...) :
Studies with model compounds show that these histone deacetylase inhibitors increase FXN messenger RNA levels in the brain in mouse models for Friedreich ataxia and relieve neurological symptoms observed in mouse models and support the notion that this class of molecules may serve as therapeutics for the human disease
Gottesfeld et al., J Neurochem 2013
:
Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich 's ataxia