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EPHB2 — GABBR1

Text-mined interactions from Literome

Tu et al., Cell Signal 2007 : It has been shown that GABA(B) receptor activates ERK ( 1/2 ) in neurons of the central nervous system, but the molecular mechanisms underlying this event are poorly characterized ... Here, we demonstrate that activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK ( 1/2 ) phosphorylation in cultured cerebellar granule neurons ... In conclusion, the activation of GABA(B) receptor leads to ERK ( 1/2 ) phosphorylation via the coupling of GABA ( B2 ) to G ( i/o ) and by releasing Gbetagamma subunits which in turn induce the activation of CREB
Baloucoune et al., PloS one 2012 (MAP Kinase Signaling System) : GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation ... Furthermore, we demonstrate that GB1asa induces ERK1/2 phosphorylation through Gi/o proteins and PLC dependent IGF-1R transactivation