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GCHFR — IFNG

Text-mined interactions from Literome

Liu et al., Cytokine 1999 (Lupus Erythematosus, Systemic) : SAC stimulated IL-12 p35 and p40 mRNAs were significantly augmented by interferon gamma (IFN-gamma)
van Seventer et al., J Neuroimmunol 2002 (Multiple Sclerosis) : We now describe how pre-incubation with 1000 U/ml of IFN-beta differentially regulates expression of multiple IL-12 family members in activated, immature human DC, inhibiting CD40/IFN-gamma induced p35 and p40 message levels, while enhancing p19 and Epstein-Barr virus induced gene 3 (EBI3) levels
Maruyama et al., J Immunol 2003 : While IFN-gamma must be present for IL-12 p40 gene induction, the p35 gene is strongly induced by LPS, even in the absence of IFN-gamma, and therefore the induction of the p35 gene is IRF-1 independent
Dahlberg et al., Virology 2006 (Cardiovirus Infections...) : In contrast to overexpressed IRF-1, IRF-5, and IRF-7, which stimulated p35 promoter reporter activity, overexpressed IRF-3 repressed p35 promoter activity in response to TMEV infection, loxoribine, IFN-gamma/LPS , but not IFN-gamma alone
Kricek et al., Eur J Immunol 1995 : After GAMD injection, two groups of induction profiles were observed in spleen, mesenteric lymph nodes and Peyer 's patches : while IL-4 and IL-12p35 gene transcription was strongly enhanced, IFN-gamma , IL-12p40 and IL-13 mRNA were only moderately induced
Ma et al., J Exp Med 1996 : We show here that IFN-gamma enhances IL-12 production mostly by priming phagocytic cells for lipopolysaccharide (LPS) induced transcription of the IL-12 p40 gene, which encodes the heavy chain of the IL-12 heterodimer ; furthermore, IFN-gamma directly induces transcription of the IL-12 p35 gene, which encodes the light chain of IL-12, and has at least an additive effect with LPS stimulation in inducing its transcription