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GDF2 — SMAD7

Text-mined interactions from Literome

Vanhara et al., Differentiation 2009 (Prostatic Neoplasms) : Moreover, GDF-15 inhibits expression of carbonic anhydrase II and cathepsin K, key osteoclast enzymes, and induces changes in SMAD and p38 signaling
Chen et al., J Bone Miner Res 2010 (Hypertrophy) : Mechanistically, IGF-2 is further shown to enhance the BMP-9 induced BMPR-Smad reporter activity and Smad1/5/8 nuclear translocation
Luo et al., J Biol Chem 2010 : Likewise, RNAi silencing of ALK1 and ALK2 expression inhibits BMP9 induced BMPR-Smad activity and osteogenic differentiation in MSCs both in vitro and in vivo
Wu et al., Acta Biochim Biophys Sin (Shanghai) 2010 : We found that three DN type II TGF-ß receptors, DN-BMPRII, DN-ActRII, and DN-ActRIIB, diminished BMP-9 induced alkaline phosphatase (ALP) activity, led to a decrease in BMP-9 induced Smad binding element ( SBE ) -controled reporter activity, reduced BMP-9 induced expressions of Smad6 and Smad7, and decreased BMP-9 induced mineralization in vitro and ectopic bone formation in vivo, finally resulted in decreased bone masses and immature osteogenesis