◀ Back to NFKB1

GFAP — NFKB1

Text-mined interactions from Literome

Bae et al., Biochim Biophys Acta 2006 : To further delineate whether NF-kappaB is directly involved in the regulation of GFAP gene expression, we transfected A172 cells with an expression vector encoding a super-repressor IkappaBalpha protein ( IkappaBalpha-SR ) to specifically inhibit NF-kappaB activity and found the marked reduction of GFAP protein levels in IkappaBalpha-SR-transfectant cells ... Taken together, our results suggest that NF-kappaB may play pivotal roles in GFAP gene expression
Brahmachari et al., J Neurosci 2006 : Interestingly, inhibition of nuclear factor kappaB (NF-kappaB) suppressed LPS- but not GSNO induced expression of GFAP, suggesting that NO does not require NF-kappaB to induce GFAP and that NF-kappaB functions upstream of NO production
Shan et al., J Biomed Biotechnol 2009 (Brain Injuries...) : Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP) , inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), inhibited nuclear translocation of nuclear factor-kappaB (NF-kappaB) , increased the activity of copper/zinc superoxide dismutase ( Cu/Zn-SOD ) and catalase (CAT), and reduced the content of malondialdehyde ( MDA ), respectively
Fu et al., Pain 2010 (Disease Models, Animal...) : As expected, following CCI nuclear translocation, and hence activation, of NF-kappaB was detected only in the sciatic nerve of wild type ( WT ) mice, and not in GFAP-IkappaBalpha-dn mice, while upregulation of GFAP was observed in the sciatic nerve and DRGs of both WT and GFAP-IkappaBalpha-dn mice, indicative of glial activation
Bachetti et al., Exp Cell Res 2010 (Astrocytoma...) : Ceftriaxone has also been shown to modulate the proteasome system, thus decreasing NF-kappaB activation and GFAP promoter transcriptional regulation , which further accounts for the down-modulation of GFAP protein levels