Gene interactions and pathways from curated databases and text-mining

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CD40 — GRAP2

Text-mined interactions from Literome

Arimura et al., J Biol Chem 2001 : CD45 is required for CD40 induced inhibition of DNA synthesis and regulation of c-Jun NH2-terminal kinase and p38 in BAL-17 B cells
Zhang et al., J Allergy Clin Immunol 2002 : CD40 activation of p38 MAPK correlated with CD40 dependent IgE production, and IgE suppression by SB203580 correlated with the inhibition of CD40 activated p38 MAPK phosphorylation
Awasthi et al., J Exp Med 2003 (Leishmaniasis, Cutaneous) : The inhibition of CD40 induced iNOS2 expression by SB203580, a p38-mitogen activated protein kinase ( p38MAPK ) -specific inhibitor, and the reversal of the inhibition by anisomycin, a p38MAPK activator, suggested a crucial role of p38MAPK in CD40 signaling ... Indeed, the CD40 induced p38MAPK phosphorylation, iNOS2 expression and anti-leishmanial function were impaired in Leishmania infected macrophages but were restored by anisomycin
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : Leishmania skews CD40 signaling toward ERK-1/2, inducing IL-10, which inhibits activation of CD40 induced p38MAPK and expression of inducible nitric oxide synthase-2 ( iNOS-2 ) and IL-12
Lee et al., Journal of cell communication and signaling 2007 : The differential requirement for ROS in the activation of ERK, JNK, p38 , and Akt by the BCR, CD40 , and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner