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GRB2 — IGF1R

Pathways - manually collected, often from reviews:

• BioCarta multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta/14-3-3 complex (IGF1R-YWHAH-IGF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta the igf-1 receptor and longevity: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta igf-1 signaling pathway: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Pathways in cancer: IGF1R → GRB2 (protein-protein, activation)
• KEGG Prostate cancer: EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB → GRB2 (protein-protein, activation)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GTP complex (HRAS) (modification, activates)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: GRB2/SOS1 complex (GRB2-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
  Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
• NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK → GRB2 (activation)
• WikiPathways Signaling Pathways in Glioblastoma: IGF1R/ERBB3/FGFR1/PDGFRA/PDGFRB/ERBB2/EGFR/FGFR2/MET → GRB2 (mim-stimulation)