Gene interactions and pathways from curated databases and text-mining

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GRB2 — IL11

Text-mined interactions from Literome

Lee et al., Phytother Res 2013 (Inflammation) : GRb1 significantly reduced the upregulation of tumor necrosis factor-a, interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Wang et al., J Biol Chem 1995 : Interleukin-11 induces complex formation of Grb2 , Fyn, and JAK2 in 3T3L1 cells ... JAK2 and Fyn are transiently associated with Grb2 upon stimulation with IL-11 , suggesting that JAK2 and Fyn may be involved in transducing signals from the IL-11 receptor-glycoprotein 130 to the Ras system through Grb2 ... Taken together, these results suggest that IL-11 induced interactions of JAK2, Fyn, and Grb2 may not only provide a novel mechanism for the activation of the Ras/MAPK system but also indicate cross-talk among diverse signaling pathways