Gene interactions and pathways from curated databases and text-mining

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EGFR — GRK4

Text-mined interactions from Literome

Ghiglione et al., Development 2002 : We show that expression of either a membrane bound form of Grk ( mbGrk ), or a secreted form of Grk ( secGrk ), in either the follicle cells or in the germline, activates the Egfr
Gao et al., FEBS Lett 2005 : Furthermore, studies with GRK2 mutants showed that neither catalytic activity nor the N-terminal domain of GRK2 was required for EGF induced GRK2-EGFR complex formation
Gao et al., Acta Biochim Biophys Sin (Shanghai) 2005 (MAP Kinase Signaling System) : We investigate the role of GRK2 on epidermal growth factor (EGF) receptor signaling, including EGF induced extracellular signal regulated kinase and mitogen activated protein kinase ( ERK/MAPK ) activation and EGFR internalization ... Overall, these data suggest that GRK2 has a regulatory role in EGF induced ERK/MAPK activation, and that the mechanisms underlying the modulatory role of GRK2 in EGFR and GPCR signaling pathways are somewhat different at least in receptor internalization