◀ Back to EGFR
EGFR — GRK4
Text-mined interactions from Literome
Ghiglione et al., Development 2002
:
We show that expression of either a membrane bound form of
Grk ( mbGrk ), or a secreted form of Grk ( secGrk ), in either the follicle cells or in the germline,
activates the
Egfr
Gao et al., FEBS Lett 2005
:
Furthermore, studies with GRK2 mutants showed that neither catalytic activity nor the N-terminal domain of
GRK2 was
required for EGF induced
GRK2-EGFR complex formation
Gao et al., Acta Biochim Biophys Sin (Shanghai) 2005
(MAP Kinase Signaling System) :
We investigate the
role of
GRK2 on
epidermal growth factor (EGF) receptor signaling, including EGF induced extracellular signal regulated kinase and mitogen activated protein kinase ( ERK/MAPK ) activation and EGFR internalization ... Overall, these data suggest that GRK2 has a regulatory role in EGF induced ERK/MAPK activation, and that the mechanisms underlying the modulatory
role of
GRK2 in
EGFR and GPCR signaling pathways are somewhat different at least in receptor internalization