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CASP8 — H2AFX

Text-mined interactions from Literome

Lu et al., Mol Cell 2006 : Taken together, these data indicated that H2AX phosphorylation is required for DNA ladder formation, but not for the activation of caspase-3 ; and the JNK/H2AX pathway cooperates with the caspase-3/CAD pathway resulting in cellular apoptosis
Zhang et al., Oncol Rep 2010 (Carcinoma, Non-Small-Cell Lung...) : We also showed that roscovitine induced an enhanced expression of gamma-H2AX , which was blocked by caspase-3 inhibition, suggesting that p21Waf1/Cip1 cleavage may interfere with DNA repair, leading to increased frequency of double strand breaks ( DSBs ) and enhanced apoptosis
Martin et al., Curr Cancer Drug Targets 2011 (Breast Neoplasms...) : Follow-up analysis of caspase activity and caspase dependent phosphorylation of histone H2AX demonstrated that the silencing of MAP3K7 enhanced CPT associated apoptosis