Gene interactions and pathways from curated databases and text-mining

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AKT1 — HDAC1

Text-mined interactions from Literome

De Sarno et al., Neuropharmacology 2002 : Two other inhibitors of histone deacetylase , a recently identified target of sodium valproate, also caused gradual increases in the phosphorylation of Akt and GSK3beta
Chen et al., J Biol Chem 2005 : Histone acetylation independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes
Lee et al., Mol Pharmacol 2008 : Finally, activation of Akt and CaM kinase II may eventually lead to the acetylation of histone residues and phosphorylation of histone deacetylase
Li et al., Cell Signal 2008 (Lymphoproliferative Disorders) : Expression of SAP in the A20 B cell line led to a marked reduction in Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR)
Lee et al., Proc Natl Acad Sci U S A 2012 : The OSS induced HDAC signaling and EC responses are mediated by phosphatidylinositol 3-kinase/Akt
Moskowitz et al., Curr Oncol Rep 2012 (Hodgkin Disease) : Additional agents that have demonstrated activity in HL include histone deacetylase inhibitors, such as panobinostat, entinostat, and mocetinostat, PI3-kinase/Akt/Mtor pathway inhibitors , such as everolimus, as well as lenalidomide and bendamustine