Gene interactions and pathways from curated databases and text-mining

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CASP10 — HDAC2

Text-mined interactions from Literome

Komata et al., Int J Oncol 2005 (Brain Neoplasms...) : Furthermore, caspase inhibition assay indicated that HDAC inhibitor induced apoptosis was caspase dependent ... Taken together, the HDAC inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9 dependent apoptosis with or without p21 mediated G1 arrest in human malignant glioma cells
Sato et al., Int J Oncol 2006 (Carcinoma, Squamous Cell...) : Moreover, these events were associated with an enhancement of reactive oxygen species ( ROS ) generation and caspase-3 activation by HDAC inhibitors
Pisalyaput et al., J Neurochem 2008 : Interestingly, SAP did not induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways
Norian et al., Journal of oncology 2009 : We found that HDAC inhibition in B-CLL cells led to increased TRAIL receptor expression, increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis
Cai et al., PloS one 2012 (Spinal Cord Injuries) : Taken together, it is suggested that : ( i ) in the presence of CtBP , CIBZ gene is involved in secondary injury process and trigger the activation of apoptotic caspase-3 and bax genes independent of p53 ; ( ii ) abrupt down-regulation of CtBP at 8 h is a sign of mitochondria dysfunction and the onset of cell death ; ( iii ) it could be used as an inhibitor or target drug of caspase-3 gene to improve spinal cord function
McCourt et al., Clin Cancer Res 2012 (Prostatic Neoplasms) : The histone deacetylase inhibitors ( HDACi ) , droxinostat and SAHA, also downregulated c-FLIP expression, induced caspase-8- and caspase-3/7 mediated apoptosis, and increased apoptosis in bicalutamide treated cells
Gu et al., Anticancer Drugs 2012 (Neuroblastoma) : Our studies showed that inhibition of HDAC decreased NB proliferation, and induced caspase activity and G1 growth arrest
Yuan et al., Zhonghua Bing Li Xue Za Zhi 2012 (Carcinoma, Squamous Cell...) : Moreover, down-regulation of HDAC2 expression significantly increased the expressions of caspase-3 and caspase-9 proteins but decreased the expressions of matrix metalloproteinases (MMP)-2 and MMP-9 proteins