Gene interactions and pathways from curated databases and text-mining

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HDAC4 — SPP1

Text-mined interactions from Literome

Vietor et al., J Biol Chem 2005 : TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase dependent
Sharma et al., Molecular cancer 2010 : Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells ... Silencing HDAC1 followed by stimulation with PMA resulted in significant decrease in OPN promoter activity suggesting that HDAC1 but not HDAC3 or HDAC4 was required for AP-1 mediated OPN transcription