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GATA4 — HEY2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Notch-mediated HES/HEY network:
HEY2/GATA4 complex (HEY2-GATA4)
→
HEY2 (HEY2)
(modification, collaborate)
Kathiriya et al., J Biol Chem 2004*, Fischer et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
HEY2/GATA4 complex (HEY2-GATA4)
→
GATA4 (GATA4)
(modification, collaborate)
Kathiriya et al., J Biol Chem 2004*, Fischer et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
HEY2 (HEY2)
→
GATA4 (GATA4)
(modification, collaborate)
Kathiriya et al., J Biol Chem 2004*, Fischer et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, assay, physical interaction
-
WikiPathways Heart Development:
HEY2
→
GATA4
(unknown)
Text-mined interactions from Literome
Fischer et al., Mol Cell Biol 2005
:
Loss of
Hey1/2 leads to elevated
GATA4/6 and ANF mRNA levels in embryoid bodies, while forced expression of Hey factors strongly represses expression of the GATA4 and GATA6 promoter in various cell lines
Xiang et al., Am J Physiol Heart Circ Physiol 2006
(Cardiomegaly) :
Furthermore,
CHF1/Hey2 binds GATA4 directly in coimmunoprecipitation assays and
inhibits the binding of
GATA4 to its recognition sequence within the ANF promoter