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HGF — RAC2

Text-mined interactions from Literome

Royal et al., Mol Biol Cell 2000 : Notably, HGF dependent activation of Rac but not Cdc42 is dependent on phosphatidylinositol 3-kinase ... HGF induces activation of the Cdc42/Rac regulated p21 activated kinase (PAK) and c-Jun N-terminal kinase, and translocation of Rac , PAK, and Rho dependent Rho-kinase to membrane ruffles
De Wever et al., FASEB J 2004 (Colonic Neoplasms...) : RhoA inactivation is determined by the epidermal growth factor (EGF)-like repeats of TNC through EGF-receptor signaling that confers a permissive and priming signal for the proinvasive activity of SF/HGF that activates Rac via c-Met
Ishibe et al., Mol Cell 2004 : These data demonstrate that the paxillin-MAPK complex serves as a central regulator of HGF stimulated FAK and Rac activation in the vicinity of focal adhesions, thus promoting the rapid focal adhesion turnover and lamellipodia extension that are required for migratory and tubulogenic responses
Chianale et al., Mol Biol Cell 2007 : We report that specific inhibition of Dgkalpha, obtained either pharmacologically by R59949 treatment, or by expression of Dgkalpha dominant negative mutant, or by small interfering RNA mediated down-regulation of endogenous Dgkalpha, impairs 1 ) HGF- and v-Src induced cell scatter and migration, without affecting the loss of intercellular adhesions ; 2 ) HGF induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling ; and 3 ) HGF induced Rac activation and membrane targeting
Chianale et al., Proc Natl Acad Sci U S A 2010 : Diacylglycerol kinase alpha mediates HGF induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI
Castillo-Lluva et al., Nat Cell Biol 2010 : Here, we identify that the small ubiquitin-like modifier ( SUMO ) E3-ligase, PIAS3, interacts with Rac1 and is required for increased Rac activation and optimal cell migration in response to hepatocyte growth factor (HGF) signalling
Attar et al., BMC cell biology 2013 : We now have found that Rac activation in response to hepatocyte growth factor (HGF) requires cytohesin 2 and Dock180 ... Furthermore, we find that knockdown of GRASP impairs hepatocyte growth factor (HGF) stimulated Rac activation and HGF stimulated epithelial migration
Hu et al., Cell Signal 2013 (Carcinoma, Hepatocellular...) : HGF also induced fluctuant PKC activation and Rac degradation