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GNB2L1 — HIF1A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A (HIF1A)
→
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A (HIF1A)
→
RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
→
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
→
RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
Hsp90 (HSP90AA1)
→
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
→
RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., Cell cycle (Georgetown, Tex.) 2007
:
RACK1 promotes the O2/PHD/VHL independent and proteasome dependent degradation of
HIF-1alpha
Liu et al., J Biol Chem 2007
:
RACK1 binds to the catalytic domain of calcineurin and is
required for
HIF-1alpha degradation induced by the calcineurin inhibitor cyclosporine A. Elongin-C and HIF-1alpha each bind to RACK1 and dimerization of RACK1 is required to recruit Elongin-C to HIF-1alpha