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AKT2 — HK2

Text-mined interactions from Literome

Gottlob et al., Genes Dev 2001 : First, Akt increases mitochondria associated hexokinase activity
Miyamoto et al., Cell Death Differ 2008 : HK-II contains consensus sequences for phosphorylation by Akt and LIF treatment induces PI3K- and Akt dependent HK-II phosphorylation
Wang et al., Neurosci Lett 2008 : The hypothesis that neurotrophic factor dependent activation of Akt would regulate hexokinase association with the mitochondria was tested and quantitative Western blotting showed no effect of blockade of the phosphoinositide 3-kinase ( PI 3-kinase ) /Akt pathway using the inhibitor LY294002, indicating this interaction of hexokinase with mitochondria was not neurotrophic factor or Akt dependent
Roberts et al., J Biol Chem 2013 : Akt , activated by insulin-like growth factor 1 (IGF-1) treatment in neonatal rat ventricular myocytes, translocates to mitochondria and increases mitochondrial HK-II binding ... These results show that Akt phosphorylation of HK-II at Thr-473 is responsible for the Akt mediated increase in HK-II binding to mitochondria
Betz et al., Proc Natl Acad Sci U S A 2013 : mTORC2 controlled MAM integrity and mitochondrial function via Akt mediated phosphorylation of the MAM associated proteins IP3R, Hexokinase 2 , and phosphofurin acidic cluster sorting protein 2