UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to LCK

HLA-A — LCK

Pathways - manually collected, often from reviews:

NCI Pathway Database TCR signaling in naïve CD8+ T cells: CSK/PAG1 complex (CSK-PAG1) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, collaborate)
Brdicka et al., J Exp Med 2000
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → Csk (CSK) (modification, activates) Brdicka et al., J Exp Med 2000
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → LCK (LCK) (modification, collaborate) Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: LCK (LCK) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → SHC (SHC1) (modification, activates) Walk et al., Eur J Immunol 1998
Evidence: expresssion pattern
NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Carrera et al., J Biol Chem 1994, Exley et al., J Biol Chem 1994, de Aós et al., J Biol Chem 1997, Zhang et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → ZAP-70 (ZAP70) (modification, collaborate) Iwashima et al., Science 1994
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: ZAP-70 (ZAP70) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1/PI3K Class IA complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, activates)
Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → PKC theta (PRKCQ) (modification, activates) Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, activates) Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species