Gene interactions and pathways from curated databases and text-mining

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HNRNPH1 — IL4

Text-mined interactions from Literome

Manome et al., Immunology 1999 (Dermatitis, Contact) : Finally, we examined the effects of these chemicals on CD86 expression by three different macrophage subsets and DCs induced from the cultures of human peripheral blood monocytes in the presence of macrophage colony stimulating factor ( M-CSF ), M-CSF + interleukin-4 (IL-4), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and GM-CSF + IL-4, respectively
Shimizu et al., J Leukoc Biol 2000 : While normal DCs pulsed with the exogenous antigen, keyhole limpet hemocyanin ( KLH ) induced specific Th1-like interferon-gamma(IFN-gamma) producing CD4+ T cell line, FK-DCs induced Th2-like interleukin-4 (IL-4) producing CD4+ T cell line
Bellinghausen et al., J Allergy Clin Immunol 2001 (Hypersensitivity, Immediate) : However, pretreatment of DCs with IL-10 inhibited the production of T ( H ) 1 and T ( H ) 2 cytokines by T cells, whereas HC-treated DCs inhibited production of IFN-gamma but induced an increased release of IL-4 and no change in IL-5
Ghaemmaghami et al., Clin Exp Allergy 2002 (Hypersensitivity, Immediate) : Furthermore, we demonstrate that DCs that have been matured in the presence of proteolytically active Der p 1 induce the production of significantly less IFN-gamma and more IL-4 by CD4 T cells, compared to DCs that have been matured in the presence of proteolytically inactive Der p 1
Calder et al., Scand J Immunol 2003 : However, stimulation with antigen pulsed DCs overexpressing IotakappaBetaalpha, the endogenous inhibitor of NF-kappaB, led to a significant reduction in T-cell proliferation, and decreased production of interferon-gamma, IL-4 and IL-10, whereas transforming growth factor-beta production was low throughout
Celluzzi et al., Transfusion 2003 : DCs cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the presence of GM-CSF + IL4 +/- TNFalpha were frozen and stored at -80 degrees C in 6-percent HES, 5-percent DMSO, and 4-percent HSA
Liu et al., Pediatr Res 2003 : Both non-BCG treated and BCG treated cord blood DCs efficiently induced a high level of IL-10, medium level of interferon-gamma, but little IL-4 production by cord blood naïve CD4+ T cells
Louis et al., Pathol Biol (Paris) 2003 (Genetic Predisposition to Disease...) : In contrast to this well established role of IL-4 in Th2 cell maturation, we have recently shown that, when limited to the initial period of activation of dendritic cells by L. major preceding T cell priming, IL-4 directs DCs to produce IL-12, promotes Th1 cell maturation and resistance to L. major in otherwise susceptible BALB/c mice
Sorg et al., J Immunother 2003 (Neoplasm Metastasis) : Mature DCs effectively clustered with naive T cells and potently induced allogeneic T-cell proliferation and IL-2 and IFNgamma but not IL-4 production
Liu et al., Chin J Cancer 2003 (Breast Neoplasms) : DCs were stimulated by granulocyte/macrophage colony stimulating factor ( GM-CSF ), interleukin-4(IL-4) , and tumor antigen
Ohshita et al., Gan To Kagaku Ryoho 2003 (Stomach Neoplasms) : DCs were induced from an adherent cell population of peripheral blood mononuclear cells ( PBMCs ) with GM-CSF and IL-4
Sauma et al., Scand J Immunol 2004 : These results illustrate a new putative role for IL-4 on the regulation of the immune response and should help clarify the controversial reports on the effect of IL-4 on DCs
Zhang et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004 : In order to compare the effects of GM-CSF + IL-4 with the effects of IL-3 + IL-4 on the differentiation and development of dendritic cells (DCs) from mouse bone marrow, we cultured bone marrow hematopoietic progenitor cell in vitro and examined whether DCs induced by IL-3 + IL-4 ( IL-3 DCs ) differed from the DCs induced by GM-CSF + IL-4 ( GM-CSF DCs ) in morphology, yields, phenotype and endocytic activity ... The results showed that the DCs induced by IL-3 + IL-4 and the DCs induced by GM-CSF + IL-4 had similar morphology, and the DCs induced by IL-3 + IL-4 expressed high level of major histocompability complex ( MHC) class II
Martino et al., J Leukoc Biol 2004 : However, BCG-DCs induced IL-4 production when cocultured with human cord-blood mononuclear cells ... The induction of IL-4 production by DCs generated by BCG infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis
Nakahara et al., Int Immunol 2004 : Although autologous T cells primed by the ovalbumin ( OVA ) -pulsed mature DCs produced IFN-gamma, but not IL-4, OVA pulsed SP600125 treated mature DCs could initiate IL-4 production from autologous T cells
Xiao et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005 (Tuberculosis) : The GM-CSF and IL-4 induced DCs from mouse bone marrow cells were transfected with recombinant plasmid pEGHsp65
Oriss et al., J Immunol 2005 (Inflammation) : DCs from both conditions induced T cell IL-4 production but the T cells cultured with tolerogenic DCs were unresponsive to IL-4 as indicated by inhibition of STAT6 activation and expression of growth factor independent 1, which has been recently shown to be important for STAT6 activated Th2 cell expansion
Sheng et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005 (Leukemia) : DCs induced by GM-CSF+IL-4 and TNF-alpha had DC-classical phenotypic characteristics
Haase et al., Blood 2005 (Diabetes Mellitus, Experimental...) : We show that FBS exposed DCs induce a systemic immune deviation characterized by reduction of virus-specific T cells, delayed viral clearance, and enhanced systemic production of interleukin 4 (IL-4) , IL-5, and IL-10 to FBS derived antigens, including bovine serum albumin ( BSA )
Wang et al., World J Gastroenterol 2005 (Carcinoma, Hepatocellular) : DCs were derived from peripheral blood mononuclear cells of healthy donors in the presence of human GM-CSF and IL-4
Jang et al., J Immunol 2006 : By presenting IEC associated Ag, the LP-DCs also induce T cells to produce IL-4 and IL-10
Sponaas et al., J Exp Med 2006 (Disease Models, Animal...) : However, although both DC subsets expressing malaria peptides could induce interferon-gamma production by CD4 T cells, only CD8- DCs isolated at the acute phase of infection stimulated Ag-specific T cell proliferation and interleukin (IL)-4 and -10 production from MSP1-specific T cell receptor for Ag transgenic T cells coincidental with our reported Th1 to Th2 switch at this stage in response to the pathogen
Hua et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : The DCs were derived from healthy human peripheral blood monocytes in the presence of granulocyte-macrophage colony stimulating factor, interleukin (IL)-4 and tumor necrosis factor (TNF) alpha
Kean et al., J Immunol 2006 : In coculture experiments using the DO11.10 transgenic T cell that recognizes OVA peptide, DCs exposed to both allergens induced T cells to produce IFN-gamma, but only Ber e 1 could induce significant production of IL-4 and IL-5
Zhong et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 : Dendritic cells(DCs) were induced from human peripheral blood mononuclear cell by GM-CSF and IL-4
Wiethe et al., J Immunol 2007 (Encephalomyelitis, Autoimmune, Experimental) : NKT cell activation by TNF matured DCs induced high serum levels of IL-4 and IL-13 which are absent in NKT cell-deficient mice, whereas LPS plus anti-CD40 treated fully mature DCs induce serum IFN-gamma
Qu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007 (Brain Neoplasms...) : The results indicated that in the presence of GM-CSF and IL-4 , the DCs with typical morphological features at days 15 were observed
Iwabuchi et al., Microbiol Immunol 2007 : Furthermore, BB536 induced the maturation of immature bone marrow derived dendritic cells ( BM-DCs ), and suppressed antigen induced IL-4 production mediated by BM-DCs
Maeda et al., Immunobiology 2007 : Pretreatment of DCs with IL-21 and alpha-galactosylceramide ( alpha-GalCer ), an NKT cell-specific ligand, resulted in the enhanced ability of the DCs to induce NKT cell production of IFN-gamma but not IL-4 in vitro compared to DCs pretreated with alpha-GalCer alone
Mizuuchi et al., Immunology 2008 : The CpG-DCs expressed significantly higher levels of H2-D ( d ) than control DCs, and blocking of the H2-D ( d ) and Ly49 receptor interaction during antigen presentation completely abolished the enhanced ability of the CpG-DCs to induce NKT-cell production of IL-4
Hibi et al., Cytotechnology 2003 : DCs from each tissue induced IL-4 secretion from naive CD4 ( + ) T cells in the presence of low dose antigenic peptide, and induced IFN-gamma production at high doses of antigen ... In conclusion, DCs from SPL, MLN and PP can induce the production of both IL-4 and IFN-gamma from naive CD4 ( + ) T cells, depending on antigen dose
Liu et al., Zhonghua Yi Xue Za Zhi 2009 : Monocyte was isolated from cord blood, DCs were induced with IL-4 & GM-CSF and modified with different concentration of GH
Liu et al., Mol Biol Rep 2011 : In this study, we developed DCs from monocytes of Sprague-Dawley ( SD ) rats in the presence of recombinant human granulocyte-macrophage colony stimulating factor ( GM-CSF ) and recombinant human interleukin-4 (IL-4)
Pochard et al., J Allergy Clin Immunol 2010 (Peanut Hypersensitivity) : Peanut pulsed DCs induced the production of IL-4 , IL-5, and IL-13, as well as IL-17 and IFN-gamma, from primed T cells
Masuda et al., Cancer Immunol Immunother 2010 (Colonic Neoplasms) : MZF treated DCs significantly stimulated both allogeneic and antigen-specific syngenic T cell responses and enhanced antigen-specific interferon-gamma (IFN-gamma) production by syngenic CD4 ( + ) T cells ; however, MZF treated DCs did not affect IL-4 production
Ma et al., Zhonghua Gan Zang Bing Za Zhi 2010 : DCs derived from normal human peripheral monocytes were activated by GM-CSF and IL-4
Lee et al., Br J Pharmacol 2010 (Asthma...) : Shikonin treated BM-DCs were poor stimulators of CD4 ( + ) T lymphocyte and induced lower levels of interleukin (IL)-4 , IL-5, IL-13 and tumour necrosis factor (TNF)-a release by responding T-cells
Yekollu et al., Diabetes 2011 (Insulin Resistance...) : Targeting Tip-DCs and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity, reduced TNF, and enhanced interleukin-4 production
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Byun et al., J Biol Chem 2012 : We further found that MAP CobT treated DCs activated naive T cells, effectively polarized CD4 ( + ) and CD8 ( + ) T cells to secrete IFN-? and IL-2, but not IL-4 and IL-10, and induced T cell proliferation
Xie et al., J Surg Res 2013 : In addition, RelB shRNAi-DCs resulted in the reduced secretion of IL-2 and interferon-? and increased levels of IL-10 and IL-4
Sofronic-Milosavljevic et al., Med Microbiol Immunol 2013 (Disease Models, Animal...) : ES L1-stimulated DCs increased production of IL-4 , IL-10 and TGF-ß, and decreased production of IFN-? and IL-17, both at the systemic level and in target organs
Khanna et al., Transplantation 1998 : In addition, however, a link was observed between the beneficial effect of donor BM and comparatively large numbers of donor major histocompatibility complex class II ( IAb+ ) -positive cells in recipients ' spleens, and in cultures of granulocyte-macrophage colony stimulating factor + interleukin-4 stimulated DCs from recipients ' BM
Ratta et al., Br J Haematol 1998 : In addition, the alloreactivity of IL-4 stimulated DCs was significantly higher than those generated in the absence of IL-4