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HSPD1 — IL6

Text-mined interactions from Literome

Kol et al., J Clin Invest 1999 : Each HSP 60 also significantly induced IL-6 production by ECs, SMCs, and macrophages to an extent similar to that induced by E. coli LPS, as assessed by enzyme linked immunosorbent assay ( ELISA )
Bajramović et al., J Neuroimmunol 2000 : Hsp60 expression was found to be enhanced in response to cytokines as diverse as IL-1beta, TNF-alpha, IL-4, IL-6 and IL-10
Gobert et al., J Biol Chem 2004 : Consistent with the observed IL-6 inducing activity of H. pylori HSP60 , soluble protein extracts of H. pylori 26695 and SS1 strains that were depleted of this protein by affinity chromatography had dramatically reduced IL-6 inducing activities ... The immunopurified HSP60 stimulated IL-6 production in macrophages ... H. pylori HSP60 induced IL-6 mRNA expression, and NF-kappaB activation in RAW 264.7 cells was abrogated in the presence of MG-132, a proteasome inhibitor
Osterloh et al., Int Immunol 2008 : LPS-free Hsp60 did not induce IL-6 , IL-12 or tumor necrosis factor alpha production in APC nor were these cytokines needed for Hsp60 mediated T cell co-stimulation in the absence of LPS
Aalberse et al., PloS one 2011 : Stimulation of CBMC with HSP60 led to CD4 ( + ) T cell proliferation and the production of various cytokines, most notably IL-10, Interferon-gamma, and IL-6
Kamalakannan et al., Microbes Infect 2012 (Filariasis...) : Recombinant Wolbachia heat shock protein 60 ( rWmhsp60 ) induces gene expression of pro-inflammatory cytokines IL-1ß, IL-6 and TNF-a in human monocytic cell line THP-1
Tabona et al., J Immunol 1998 : Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation