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CA2 — IDH2
Text-mined interactions from Literome
Zammit et al., Biochem J 1976
:
The opposite
effects of
Ca2+ on the activities of
isocitrate dehydrogenase and mitochondrial glycerol phosphate dehydrogenase from muscle tissue are consistent with the hypothesis that changes in the intracellular distribution of Ca2+ control the activities of these two enzymes in order to stimulate energy production for the contraction process in the muscle
Murphy et al., J Biol Chem 1990
(Liver Neoplasms, Experimental) :
The
stimulation of 2-oxoglutarate and NAD ( + )
-isocitrate dehydrogenase by
Ca2+ in mitochondria from normal tissues has been proposed to mediate partially the activation of oxidative energy metabolism elicited by physiological elevations in cytosolic Ca2+
Denton et al., Biochem J 1978
:
The
effects of
Ca2+ on the activity of
isocitrate dehydrogenase ( NAD+ ) in extracts of rat heart mitochondria were explored in the presence of MgCl2 by using EGTA buffers
McCormack et al., Biochim Biophys Acta 1988
:
Similarly,
Ca2+ dependent activations of
NAD+-isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase could be demonstrated in intact, fully coupled, rat kidney mitochondria by either following O2 uptake ( in the presence of ADP ) and NAD ( P ) H reduction ( in the absence of ADP ) on presentation of non saturating concentrations of either threo-Ds-isocitrate or 2-oxoglutarate, respectively, under appropriate conditions, or for the latter enzyme only, also by following 14CO2 production from 2-oxo [ 1-14C ] glutarate ( in the absence or presence of ADP )
Bulos et al., J Biol Chem 1984
:
Free
Ca2+ was shown to
inhibit the
NAD+-isocitrate dehydrogenase from blowfly flight muscle mitochondria ... That
NAD+-isocitrate dehydrogenase from blowfly flight muscle mitochondria was not
activated by micromolar free
Ca2+ is consistent with the view that calcium does not play a role in regulating the flux through the tricarboxylate cycle in this species
McCormack et al., Biochem J 1980
:
3. Overall, the results of this study demonstrate that the activities of pyruvate dehydrogenase,
NAD+-isocitrate dehydrogenase and oxoglutarate dehydrogenase may all be
increased by
Ca2+ and Sr2+ within intact mitochondria
StrumiĆo et al., Acta biochimica Polonica 1995
:
Effect of
Ca2+ on the activity of mitochondrial NADP-specific
isocitrate dehydrogenase from rabbit adrenals