Gene interactions and pathways from curated databases and text-mining

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CA2 — IDH2

Text-mined interactions from Literome

Zammit et al., Biochem J 1976 : The opposite effects of Ca2+ on the activities of isocitrate dehydrogenase and mitochondrial glycerol phosphate dehydrogenase from muscle tissue are consistent with the hypothesis that changes in the intracellular distribution of Ca2+ control the activities of these two enzymes in order to stimulate energy production for the contraction process in the muscle
Murphy et al., J Biol Chem 1990 (Liver Neoplasms, Experimental) : The stimulation of 2-oxoglutarate and NAD ( + ) -isocitrate dehydrogenase by Ca2+ in mitochondria from normal tissues has been proposed to mediate partially the activation of oxidative energy metabolism elicited by physiological elevations in cytosolic Ca2+
Denton et al., Biochem J 1978 : The effects of Ca2+ on the activity of isocitrate dehydrogenase ( NAD+ ) in extracts of rat heart mitochondria were explored in the presence of MgCl2 by using EGTA buffers
McCormack et al., Biochim Biophys Acta 1988 : Similarly, Ca2+ dependent activations of NAD+-isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase could be demonstrated in intact, fully coupled, rat kidney mitochondria by either following O2 uptake ( in the presence of ADP ) and NAD ( P ) H reduction ( in the absence of ADP ) on presentation of non saturating concentrations of either threo-Ds-isocitrate or 2-oxoglutarate, respectively, under appropriate conditions, or for the latter enzyme only, also by following 14CO2 production from 2-oxo [ 1-14C ] glutarate ( in the absence or presence of ADP )
Bulos et al., J Biol Chem 1984 : Free Ca2+ was shown to inhibit the NAD+-isocitrate dehydrogenase from blowfly flight muscle mitochondria ... That NAD+-isocitrate dehydrogenase from blowfly flight muscle mitochondria was not activated by micromolar free Ca2+ is consistent with the view that calcium does not play a role in regulating the flux through the tricarboxylate cycle in this species
McCormack et al., Biochem J 1980 : 3. Overall, the results of this study demonstrate that the activities of pyruvate dehydrogenase, NAD+-isocitrate dehydrogenase and oxoglutarate dehydrogenase may all be increased by Ca2+ and Sr2+ within intact mitochondria
StrumiƂo et al., Acta biochimica Polonica 1995 : Effect of Ca2+ on the activity of mitochondrial NADP-specific isocitrate dehydrogenase from rabbit adrenals