◀ Back to JAK1
IFNA7 — JAK1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IFNA7
→
JAK1
(reaction)
Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997
-
Reactome Reaction:
IFNA7
→
JAK1
(indirect_complex)
You et al., Mol Cell Biol 1999, Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997
Text-mined interactions from Literome
Li et al., Oncogene 1999
:
The human papilloma virus ( HPV ) -18 E6 oncoprotein physically associates with Tyk2 and impairs
Jak-STAT activation by
interferon-alpha
Joo et al., Arch Pharm Res 2006
:
In our study, we were able to determine that DDB stimulates
Jak/Stat signaling, and
induces the expression of
interferon alpha ( IFN-alpha ) stimulated genes, most notably 6-16 and ISG12
Wang et al., Nat Immunol 2008
:
CaMK and Pyk2 relayed signals from integrins and the ITAM containing adaptor DAP12 to augment interleukin 10- and
interferon-alpha induced
Jak activation and STAT1 dependent gene expression
Platanias et al., J Biol Chem 1996
:
Binding of
interferon alpha ( IFN alpha ) to its receptor
induces activation of the Tyk-2 and
Jak-1 tyrosine kinases and tyrosine phosphorylation of multiple downstream signaling elements, including the Stat components of the interferon stimulated gene factor 3 ( ISGF-3 )
Novak et al., Growth Factors 1996
:
Instead of increased phosphorylation of JAK1 and JAK2 in response to G-CSF and interferon-gamma, and
JAK1 and Tyk2 in
response to
interferon-alpha/beta , we observed only an increase of phosphorylation of Tyk2 in response to all of these cytokines in NFS-60 cells
Krishnan et al., Eur J Biochem 1997
:
Kinase-deficient forms of
Jak1 and Tyk2
inhibit interferon alpha signaling in a dominant manner