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IGF1 — MAT2A

Text-mined interactions from Literome

Chen et al., Gastroenterology 2007 (Colonic Neoplasms...) : Epidermal growth factor, insulin-like growth factor 1 , and leptin increased growth and up-regulated MAT2A expression and MAT2A promoter activity in RKO and HT-29 cells
Yang et al., Biochem J 2011 (Colonic Neoplasms) : Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells ... The aim of the present study was to elucidate the molecular mechanisms of IGF-1 mediated MAT2A induction ... IGF-1 induced MAT2A promoter activity and increased nuclear protein binding to USF ( upstream stimulatory factor ) /c-Myb, YY1 ( Yin and Yang 1 ), E2F, AP-1 ( activator protein 1 ) and NF-?B ( nuclear factor ?B ) consensus elements ... Knockdown of p65, MafG, c-Myb or E2F-1 lowered basal MAT2A expression and blunted the inductive effect of IGF-1 on MAT2A, whereas knockdown of YY1 increased basal MAT2A expression and had no effect on IGF-1 mediated MAT2A induction ... Consistently, mutation of AP-1, NF-?B, E2F and USF/c-Myb elements individually blunted the IGF-1 mediated increase in MAT2A promoter activity, and combined mutations completely prevented the increase ... In conclusion, IGF-1 activates MAT2A transcription by both known and novel pathways