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IGF1 — SPP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Strayhorn et al., J Periodontol 1999
:
Northern analysis revealed that PDGF blocked gene expression of osteopontin (OPN) and osteocalcin ( OCN ), while BP and
IGF promoted gene expression of bone sialoprotein ( BSP ) and
OPN
Chutivongse et al., Biochem Biophys Res Commun 2005
:
The purpose of this study was to examine the
effects of type I collagen and
insulin-like growth factor-I (IGF-I) on
osteopontin (OPN) expression ... Addition of IGF-I obviously induced OPN expression only in a collagen coated condition, suggesting an attenuating
effect of
IGF-I on the decrease of
OPN expression
Tanaka et al., J Cell Physiol 1995
:
The stimulatory effect of PDGF on
osteopontin expression was
augmented by
IGF-I
Barak-Shalom et al., Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1995
:
FGF and TGF beta, but not
IGF-I or IGF-II, also
caused phosphorylation of
osteopontin
Tanaka et al., Bone 1994
(Bone Diseases, Metabolic...) :
IGF-I ( 50 ng/ml )
stimulates the expression of alkaline phosphatase, procollagen alpha 1 ( I ),
osteopontin and osteocalcin mRNA in stromal cells from both adult and old rats
Padanilam et al., Endocrinology 1996
(Ischemia...) :
IGF-I enhanced expression of
osteopontin at an earlier time postischemia may ameliorate the course of injury