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IGF1R — VHL
Text-mined interactions from Literome
Yuen et al., Oncogene 2007
(Carcinoma, Renal Cell...) :
In Sp1-null Drosophila Schneider cells,
IGF1R promoter activity was dependent on exogenous Sp1, and was
suppressed by full-length VHL protein ( pVHL ) but only partially by truncated
VHL lacking the Sp1 binding motif ... Thus, we have identified a new hypoxia independent
role for
VHL in suppressing
IGF1R transcription and mRNA stability
Yuen et al., Mol Cancer Ther 2009
(Carcinoma, Renal Cell...) :
We recently showed that
IGF1R expression is
inhibited by the
von Hippel-Lindau (VHL) tumor suppressor , and the IGF1R is up-regulated in CC-RCC, in which VHL is frequently inactivated