Gene interactions and pathways from curated databases and text-mining

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IGF1R — VHL

Text-mined interactions from Literome

Yuen et al., Oncogene 2007 (Carcinoma, Renal Cell...) : In Sp1-null Drosophila Schneider cells, IGF1R promoter activity was dependent on exogenous Sp1, and was suppressed by full-length VHL protein ( pVHL ) but only partially by truncated VHL lacking the Sp1 binding motif ... Thus, we have identified a new hypoxia independent role for VHL in suppressing IGF1R transcription and mRNA stability
Yuen et al., Mol Cancer Ther 2009 (Carcinoma, Renal Cell...) : We recently showed that IGF1R expression is inhibited by the von Hippel-Lindau (VHL) tumor suppressor , and the IGF1R is up-regulated in CC-RCC, in which VHL is frequently inactivated