Gene interactions and pathways from curated databases and text-mining

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IGF1 — IGF2R

Text-mined interactions from Literome

Damke et al., Biochem J 1992 : IGF-I , IGF-II and phorbol ester increased the surface expression of the M6P/IGF-II receptor and of MPR46 ... IGF-I, IGF-II and phorbol ester increased the surface expression of the M6P/IGF-II receptor and of MPR46
MacDonald et al., Endocrinology 1991 : Furthermore, Man-6-P enhanced [ 125I ] IGF-II cross linking to the H-35 receptor by a constant ( approximately 80 % ) increment 1 ) when the cross linking reaction was conducted in buffers of different pH over the range 6.8-8.0, or 2 ) using cross linking agents differing in spacer arm length from 6.4-16.1 A. Washing membranes before assay with either Man-6-P ( pH 7.4 ) or 0.5 M NaCl ( pH 4.5 ) reduced the subsequent Man-6-P enhancement of [ 125I ] IGF-II-receptor cross linking, suggesting that this phenomenon was actually due to displacement of inhibitory phosphomannosyl ligands bound endogenously to the Man-6-P sites of the receptor
Zou et al., Cancer Res 1998 (Gastrointestinal Neoplasms) : IGF-I and IGF-II levels are regulated by binding to the IGF-II receptor , which is inactivated by mutation in human gastrointestinal ( GI ) tumors