Gene interactions and pathways from curated databases and text-mining

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IL12A — IL1B

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

de Haan et al., Transplantation 2000 : In this assay also the effects of anti-CD28 antibody and interleukin- (IL) 1beta , IL-6, or IL-12 mediated costimulation on responder T cell proliferation and IL-2 production were investigated
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : However, IL-1beta , but not IFN-gamma, induced IL-12 p40 production by DCs without enhancing phenotypic maturation
Roggen et al., Toxicol Lett 2006 (Hypersensitivity) : PGE ( 2 ) is synergistic with IL-1beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production
Mpiga et al., Scand J Immunol 2006 (Chlamydia Infections) : When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained, IL-1beta expression followed a bell shaped curve and IL-10, IL-12p70 and TNF-alpha synthesis was down regulated
Nold-Petry et al., J Biol Chem 2009 (MAP Kinase Signaling System) : In addition, we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and IL-12/IL-18 induced IL-1beta , IL-6, interferon-gamma, and CD40L
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta , IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27, IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Kato et al., Glycoconj J 2010 : Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9, induced production of IL-12 and tumor necrosis factor (TNF)-alpha from PEMs, while secretion of IL-6 and IL-1beta was not detected with the same treatment
Seitz et al., Eur J Immunol 1996 : In contrast, IL-12 stimulated the production of IL-1 beta and MCP-1 in TNF-alpha stimulated MNC and inhibited IL-1ra synthesis in cytokine stimulated cells