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IL12B — NFKB1

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: NFKB1/RELA → IL12A/IL12B (protein-protein, expression)
• KEGG Tuberculosis: NFKB1/RELA → IL12A/IL12B (gene expression, expression)

Text-mined interactions from Literome

Delgado et al., J Biol Chem 1999 : VIP and PACAP inhibit IL-12 ( p40 ) gene expression by affecting both NF-kappaB binding and the composition of the Ets-2 binding complex
Kang et al., Immunol Lett 1999 : Our results show that TPCK and TLCK inhibit NFkappaB mediated IL-12 production in macrophages
Du et al., Cell Immunol 2000 : SEB induced expression of the IL-12/p40 gene involves activation and nuclear translocation of nuclear factor kappaB (NF-kappaB)
Schindler et al., J Immunol 2001 : NF-kappa B , which mediates IL-18 effects in T cells, was only weakly activated by IL-12 and/or IL-18 in macrophages
Grumont et al., J Exp Med 2001 : This data establishes the IL-12 p35 gene as a new target of c-Rel and shows that the regulation of IL-12 p70 expression at the transcriptional level by Rel/NF-kappaB is controlled through both the p35 and p40 genes in a cell type-specific fashion
Säemann et al., J Leukoc Biol 2002 : In particular, n-butyrate prevents homotypic DC clustering, inhibits IL-12 while sparing IL-10 production, and at the molecular level, blocks NF-kappa B translocation
Maruyama et al., J Immunol 2003 : The induction of the IL-12 p40 gene is regulated by NF-kappaB in the presence of IFN-gamma
Kuroki et al., Cancer Immunol Immunother 2003 : These results indicate that uptake of OK-432 by imMo-DCs is an early critical event for IL-12 p70 production and that NF-kappaB activation induced by OK-432 also contributes partially to IL-12 p70 production
Ma et al., J Immunol 2004 : Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS stimulated human monocytic cells by down regulating the activation of JNK MAPK, the AP-1, and NF-kappaB transcription factors
Hoentjen et al., Blood 2005 : In this study, we investigated the role of nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription 3 ( STAT3 ) in lipopolysaccharide (LPS) induced IL-12p40 gene expression in bone marrow derived-dendritic cells ( BMDCs ) isolated from wild-type ( WT ) and IL-10 ( -/- ) mice ... In conclusion, dysregulated LPS induced IL-12p40 gene expression in IL-10 ( -/- ) mice is due to enhanced NF-kappaB recruitment to the IL-12p40 promoter in the absence of activated STAT3
Mason et al., Infect Immun 2004 : Recent studies suggest that components of the TLR pathway are required for the production of IL-12 in response to the parasite Toxoplasma gondii ; however, the production of IL-12 in response to this parasite is independent of NF-kappaB activation
Chang et al., Mol Cells 2004 (Inflammation...) : Activation of NF-kappaB leads to the production of proinflammatory cytokines such as IL-12 and TNF-alpha that are involved in innate and adaptive immunity
Kabashima et al., FEBS Lett 2004 (Hypersensitivity, Delayed...) : Here, we found that our recently synthesized NF-kappaB inhibitor attenuated an ovalbumin-specific delayed-type hypersensitivity response in vivo and suppressed production of IL-12 by dendritic cells and TH1 cytokines by T cells in vitro
Rahim et al., Immunology 2005 : In a complementary experiment, in vitro transient expression of p65 NF-kappaB could not rescue the inhibitory effect of IL-10 on IL-12 production, suggesting that NF-kappaB alone was not sufficient to restore IL-12 production during IL-10 treatment
Kang et al., Cell Signal 2005 (Autoimmune Diseases) : IL-12 production is differentially regulated through multiple pathways, which can be classified as follows : nuclear factor-kappaB (NF-kappaB) and other transcription factors, p38 mitogen activated protein ( MAP ) kinase, cyclic adenosine monophosphate ( cyclic AMP ) -modulating molecules, cell membrane ion channels and pumps, nitric oxide ( NO ), and receptors
Yue et al., Proc Natl Acad Sci U S A 2005 : Selective NF-kappaB inhibition blocked this CD1d stimulated IL-12 production
Filipe-Santos et al., J Exp Med 2006 (Genetic Predisposition to Disease...) : IL-12 production was also impaired as the result of a specific defect in NEMO- and NF-kappaB/c-Rel mediated CD40 signaling after the stimulation of monocytes and dendritic cells by CD40L expressing T cells and fibroblasts, respectively ... They also demonstrate the importance of the T cell- and CD40L triggered, CD40-, and NEMO/NF-kappaB/c-Rel mediated induction of IL-12 by monocyte derived cells for protective immunity to mycobacteria in humans
Usluoglu et al., Eur J Immunol 2007 : Different signal pathways mediate LPS induced expression of IL-12 and involve PI3K, MAPK and the transcription factor NF-kappaB
Homma et al., J Interferon Cytokine Res 2007 : The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation
Jayakumar et al., Infect Immun 2008 : The inhibition of NF-kappaB activation by the pretreatment of DC with caffeic acid phenethyl ester blocks L. major induced IRF-1 and IRF-8 activation and IL-12 expression
Argueta-Donohué et al., Exp Parasitol 2008 : Leishmania mexicana : participation of NF-kappaB in the differential production of IL-12 in dendritic cells and monocytes induced by lipophosphoglycan ( LPG )
Ju et al., J Immunol 2008 (Arthritis, Experimental...) : IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model
Ma et al., J Biol Chem 2009 (Acquired Immunodeficiency Syndrome) : HIV-1 Nef inhibits lipopolysaccharide induced IL-12p40 expression by inhibiting JNK activated NFkappaB in human monocytic cells ... We have previously shown that lipopolysaccharide (LPS) induced IL-12p40 production in monocytic cells is regulated by NFkappaB and AP-1 transcription factors through the activation of two distinct upstream signaling pathways, namely the c-Jun-N-terminal kinase (JNK) and the calmodulin dependent protein kinase-II activated pathways
Rigaux et al., Allergy 2009 (Hypersensitivity) : IL-12 p40 secretion was dependent on nuclear factor-kappaB (NF-kappaB) , mitogen activated protein ( MAP ) kinases, Toll-like receptor 2 (TLR2), TLR9 and on the bacterial teichoic acid composition
Kortylewski et al., Cancer Cell 2009 (Neoplasms) : Furthermore, Stat3 inhibits NF-kappaB/c-Rel dependent IL-12/p35 gene expression in tumor associated dendritic cells
Kang et al., Cytokine 2009 : Induction of IL-12 by LMM in peritoneal macrophages involved NF-kappaB , p38 and JNK, but not ERK1/2
Li et al., Immunol Lett 2010 (Arthritis, Rheumatoid...) : IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways
Antonios et al., J Immunol 2010 (MAP Kinase Signaling System) : Our results showed that p38 MAPK, NF-kappaB , and IRF-1 were involved in IL-12p40 production induced by NiSO ( 4 )
Kato et al., Glycoconj J 2010 : SIGNR1 ligation on murine peritoneal macrophages induces IL-12 production through NFkappaB activation ... These results indicate that SIGNR1 mediated intercellular signaling may induce production of cytokines such as IL-12 through NFkappaB activation
Zhao et al., PloS one 2012 : Nfkb1 inhibits LPS induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms
Mazzeo et al., Eur J Immunol 1998 : Decreased IL-12 production and Th1 cell development by acetyl salicylic acid mediated inhibition of NF-kappaB ... These results suggest that the inhibition of NF-kappaB activation by ASA leads to down-regulation of IL-12 production and inhibition of Th1 cell development